{"id":18129,"date":"2018-01-24T08:50:29","date_gmt":"2018-01-24T11:50:29","guid":{"rendered":"https:\/\/www.infobioquimica.com\/new\/?p=18129"},"modified":"2018-01-24T08:50:29","modified_gmt":"2018-01-24T11:50:29","slug":"complete-genes-may-pass-from-food-to-human-blood","status":"publish","type":"post","link":"https:\/\/infobioquimica.com\/new\/2018\/01\/24\/complete-genes-may-pass-from-food-to-human-blood\/","title":{"rendered":"Complete Genes May Pass from Food to Human Blood"},"content":{"rendered":"

Our bloodstream is considered to be an environment well separated from the outside world and the digestive tract. According to the standard paradigm large macromolecules consumed with food cannot pass directly to the circulatory system. During digestion proteins and DNA are thought to be degraded into small constituents, amino acids and nucleic acids, respectively, and then absorbed by a complex active process and distributed to various parts of the body through the circulation system. Here, based on the analysis of over 1000 human samples from four independent studies, we report evidence that meal-derived DNA fragments which are large enough to carry complete genes can avoid degradation and through an unknown mechanism enter the human circulation system. In one of the blood samples the relative concentration of plant DNA is higher than the human DNA. The plant DNA concentration shows a surprisingly precise log-normal distribution in the plasma samples while non-plasma (cord blood) control sample was found to be free of plant DNA.<\/p>\n

Authors:<\/strong> S\u00e1ndor Spis\u00e1k1,2*<\/sup>, Norbert Solymosi3,4<\/sup>, P\u00e9ter Ittz\u00e9s3<\/sup>, Andr\u00e1s Bodor3<\/sup>, D\u00e1niel Kondor3<\/sup>, G\u00e1bor Vattay3<\/sup>, Barbara K. Bart\u00e1k5<\/sup>,\u00a0Ferenc Sipos5<\/sup>, Orsolya Galamb5<\/sup>, Zsolt Tulassay1,5<\/sup>, Zolt\u00e1n Sz\u00e1ll\u00e1si2<\/sup>, Simon Rasmussen6<\/sup>, Thomas Sicheritz-Ponten6<\/sup>, S\u00f8ren Brunak6<\/sup>, B\u00e9la Moln\u00e1r1,5<\/sup>, Istv\u00e1n Csabai3,7<\/sup><\/p>\n

    \n
  1. Molecular Medicine Research Group, Hungarian Academy of Sciences, Budapest, Hungary,<\/li>\n
  2. Children\u2019s Hospital, Harvard Medical School, Boston, Massachusetts, United
    \nStates of America,<\/li>\n
  3. Department of Physics of Complex Systems, Eo\u00a8tvo\u00a8s University, Budapest, Hungary,<\/li>\n
  4. Department of Animal Hygiene, Herd Health and Veterinary Ethology, Szent Istva\u00b4n University, Budapest, Hungary,<\/li>\n
  5. 2nd Department of Internal Medicine, Semmelweis University, Budapest, Hungary,<\/li>\n
  6. Center for Biological Sequence Analysis, Technical University of Denmark, Lyngby, Denmark,<\/li>\n
  7. Department of Physics and Astronomy, The Johns Hopkins University, Baltimore, Maryland,\u00a0United States of America<\/li>\n<\/ol>\n

    Citation:\u00a0<\/strong>Complete Genes May Pass from Food to Human Blood. PLoS ONE 8(7): e69805. https:\/\/doi.org\/10.1371\/journal.pone.0069805<\/p>\n

    Download PDF<\/a><\/h3>\n","protected":false},"excerpt":{"rendered":"

    Our bloodstream is considered to be an environment well separated from the outside world and the digestive tract. According to the standard paradigm large macromolecules consumed with food cannot pass directly to the circulatory system. During digestion proteins and DNA are thought to be degraded into small constituents, amino acids and nucleic acids, respectively, and […]<\/p>\n","protected":false},"author":2620,"featured_media":18131,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"twitterCardType":"summary_large_image","cardImageID":0,"cardImage":"","cardTitle":"","cardDesc":"","cardImageAlt":"","cardPlayer":"","cardPlayerWidth":0,"cardPlayerHeight":0,"cardPlayerStream":"","cardPlayerCodec":"","footnotes":""},"categories":[655],"tags":[32323,11839,11529,32309,32311,32319,6903,5409,14346,4905,32313,32307,13182,32315,32321,32317,11531,32305,32325,32327,5645,4289],"class_list":["post-18129","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-noticias-ingles","tag-amino-acids","tag-baltimore-en","tag-boston","tag-budapest","tag-childrens-hospital","tag-digestive-tract","tag-dna-en","tag-gene","tag-genes-en","tag-genetics","tag-harvard-medical-school","tag-hungarian-academy-of-sciences","tag-hungary","tag-johns-hopkins-university","tag-macromolecules","tag-maryland","tag-massachusetts","tag-molecular-medicine-research-group","tag-nucleic-acids","tag-proteins","tag-united-states-of-america","tag-usa"],"acf":[],"_links":{"self":[{"href":"https:\/\/infobioquimica.com\/new\/wp-json\/wp\/v2\/posts\/18129","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/infobioquimica.com\/new\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/infobioquimica.com\/new\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/infobioquimica.com\/new\/wp-json\/wp\/v2\/users\/2620"}],"replies":[{"embeddable":true,"href":"https:\/\/infobioquimica.com\/new\/wp-json\/wp\/v2\/comments?post=18129"}],"version-history":[{"count":1,"href":"https:\/\/infobioquimica.com\/new\/wp-json\/wp\/v2\/posts\/18129\/revisions"}],"predecessor-version":[{"id":18132,"href":"https:\/\/infobioquimica.com\/new\/wp-json\/wp\/v2\/posts\/18129\/revisions\/18132"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/infobioquimica.com\/new\/wp-json\/wp\/v2\/media\/18131"}],"wp:attachment":[{"href":"https:\/\/infobioquimica.com\/new\/wp-json\/wp\/v2\/media?parent=18129"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/infobioquimica.com\/new\/wp-json\/wp\/v2\/categories?post=18129"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/infobioquimica.com\/new\/wp-json\/wp\/v2\/tags?post=18129"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}