{"id":10870,"date":"2016-08-19T13:51:27","date_gmt":"2016-08-19T16:51:27","guid":{"rendered":"https:\/\/www.infobioquimica.com\/new\/?p=10870"},"modified":"2016-08-19T13:51:27","modified_gmt":"2016-08-19T16:51:27","slug":"scientists-investigate-how-multidrug-resistant-pathogens-are-brought-into-hospitals","status":"publish","type":"post","link":"https:\/\/infobioquimica.com\/new\/2016\/08\/19\/scientists-investigate-how-multidrug-resistant-pathogens-are-brought-into-hospitals\/","title":{"rendered":"Scientists Investigate How Multidrug-Resistant Pathogens are Brought into Hospitals"},"content":{"rendered":"

But where do these pathogens come from?<\/strong> In largest study of its kind in Europe, DZIF scientists from the University of Cologne investigated this question and discovered that almost 10%\u00a0of patients admitted into hospitals already bring these dreaded pathogens along with them from home.<\/strong><\/p>\n

\u00abWe were surprised that on hospital admission almost every tenth patient is colonized with multidrug-resistant pathogens,\u00bb explains Dr. Axel Hamprecht from the University of Cologne. He coordinated this study, in which six German university hospitals participated, together with Prof. Harald Seifert, also from the University of Cologne, and colleagues from Charit\u00e9 Berlin. Over 4,000 adults were tested for multidrug-resistant Enterobacteriaceae<\/em> on admission into hospital by means of stool samples or rectal swabs.<\/p>\n

Enterobacteriaceae<\/em> such as Escherichia coli<\/em> constitute a normal part of the gut flora<\/strong> and are not pathogenic–as long as they remain in the gut. However, they can cause infections<\/strong> in other organs, for example urinary tract infections<\/strong>. An infection caused by multidrug-resistant bacteria<\/strong> is much more difficult to treat and requires the use of last-resort antibiotics<\/strong>. In their investigations, the researchers paid particular attention to a group of multidrug-resistant bacteria<\/strong> that are often problematic in hospitals: so-called third-generation cephalosporin-resistant Enterobacteriaceae (3GCREB)<\/strong>.<\/p>\n

These multidrug-resistant gut bacteria which are resistant to cephalosporins,<\/strong> amongst other drugs, have spread worldwide over the past years. Similar to penicillin, cephalosporins are antibiotics that kill bacteria by inhibiting bacterial cell wall synthesis. Newer third-generation cephalosporins are effective against a broad spectrum of bacteria and belong to the group of most commonly used antibiotics. However, over the course of time, the bacteria have defend-ed themselves and have acquired so-called beta-lactamase,\u00a0an enzyme that renders these antibiotics ineffective. Enterobacteriaceae<\/em> are transmitted by smear infection, predominantly via faeces and food.<\/p>\n

Every tenth patient brings the pathogens into hospital<\/h4>\n

Out of the 4,376 adults who were tested for 3GCREB pathogens<\/strong> on admission to one of the participating hospitals, 416 were carriers of these multidrug-resistant pathogens. This prevalence is higher than has previously been reported in Germany. Especially often, the scientists found beta-lactamase producing Escherichia coli bacteria, so-called ESBL-producing Entero-bacteriaceae. The prevalence of these multidrug-resistant pathogens differed from hospital to hospital.<\/p>\n

In order to elucidate the factors for colonisation with these bacteria, the patients completed a questionnaire on previous hospital stays and lifestyle habits. \u00abPatients who have taken antibiotics and travellers outside Europe are at higher risk,\u00bb says Hamprecht, underlining two important research findings.<\/p>\n

Experts recommend more hygiene and using fewer antibiotics<\/h4>\n

What can be done to prevent the spread of multidrug-resistant pathogens as early as possible? Hamprecht is certain, \u00abWith so many people affected, the strategy of isolating patients within the hospitals no longer works. Additionally, in contrast to other groups of multidrug-resistant bacteria such as MRSA (Methicillin-resistant Staphylococcus-aureus) strains, standardised sanitation measures for 3GCREB have not been established.\u00bb Instead, Hamprecht and Seifert recommend improving hygiene measures in hospitals and practices, a rational use of antibiotics and especially reducing their non-justified administration, as well as more training for doctors.<\/p>\n

Publication<\/strong>: Colonization with third-generation cephalosporin-resistant Enterobacteriaceae on hospital admission: prevalence and risk factors.<\/em> A. Hamprecht et al. Journal of Antimicrobial Chemotherapy<\/a> (2016)<\/p>\n

Source:<\/strong> SciCasts<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

But where do these pathogens come from? In largest study of its kind in Europe, DZIF scientists from the University of Cologne investigated this question and discovered that almost 10%\u00a0of patients admitted into hospitals already bring these dreaded pathogens along with them from home. \u00abWe were surprised that on hospital admission almost every tenth patient […]<\/p>\n","protected":false},"author":2620,"featured_media":10871,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"twitterCardType":"summary_large_image","cardImageID":0,"cardImage":"","cardTitle":"","cardDesc":"","cardImageAlt":"","cardPlayer":"","cardPlayerWidth":0,"cardPlayerHeight":0,"cardPlayerStream":"","cardPlayerCodec":"","footnotes":""},"categories":[655],"tags":[13306,7915,13290,13304,13294,13296,13292,13308,13300,13298,13310,13312,8376,13302,13288,11265],"class_list":["post-10870","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-noticias-ingles","tag-3gcreb-pathogens","tag-antibiotics","tag-axel-hamprecht","tag-cephalosporins","tag-enterobacteriaceae","tag-gut-flora","tag-harald-seifert","tag-hygiene","tag-last-resort-antibiotics","tag-multidrug-resistant-bacteria","tag-national-reference-center-for-surveillance-of-nosocomial-infections","tag-nosocomial-infections","tag-pathogens","tag-third-generation-cephalosporin-resistant-enterobacteriaceae-3gcreb","tag-university-of-cologne","tag-urinary-tract-infection-en"],"acf":[],"_links":{"self":[{"href":"https:\/\/infobioquimica.com\/new\/wp-json\/wp\/v2\/posts\/10870","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/infobioquimica.com\/new\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/infobioquimica.com\/new\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/infobioquimica.com\/new\/wp-json\/wp\/v2\/users\/2620"}],"replies":[{"embeddable":true,"href":"https:\/\/infobioquimica.com\/new\/wp-json\/wp\/v2\/comments?post=10870"}],"version-history":[{"count":1,"href":"https:\/\/infobioquimica.com\/new\/wp-json\/wp\/v2\/posts\/10870\/revisions"}],"predecessor-version":[{"id":10872,"href":"https:\/\/infobioquimica.com\/new\/wp-json\/wp\/v2\/posts\/10870\/revisions\/10872"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/infobioquimica.com\/new\/wp-json\/wp\/v2\/media\/10871"}],"wp:attachment":[{"href":"https:\/\/infobioquimica.com\/new\/wp-json\/wp\/v2\/media?parent=10870"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/infobioquimica.com\/new\/wp-json\/wp\/v2\/categories?post=10870"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/infobioquimica.com\/new\/wp-json\/wp\/v2\/tags?post=10870"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}